Piroxicam Capsules 20mg (single strength leaflet)

Due to technical difficulties in printing the label-leaflet format, please find the relevant text below. Text is representative of the leaflet portion of label-leaflet spec no 50110507.

Piroxicam Capsules 20mg

• Please read this leaflet carefully before you start to take your medicine.


• It gives you important information about your medicine.


• If you want to know more, or you are not sure about anything, ask your pharmacist or doctor.


• Keep the leaflet until you have finished the medicine.

What's In Your Medicine

Piroxicam Capsules are pink and contain 20mg of Piroxicam. The capsules also contain: carmellose sodium, gelatin, lactose, magnesium stearate, maize starch, polysorbate, shellac glaze, E127, E171, EI72.

Piroxicam Capsules are available in pack sizes of 28.

Piroxicam is one of a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs).

Product Licence holder/Manufacturer:

Actavis

Barnstaple

EX32 8NS

UK

About Your Medicine

The name of your medicine is piroxicam which is the generic (common) name. Your doctor may have given you this medicine before from another company and it may have looked slightly different. Either brand will have the same effect.

Piroxicam Capsules are used to treat:

• the relief of pain, stiffness and inflammation in such conditions as arthritis, ankylosing spondylitis, low back pain, gout attacks, sprains, strains and other injuries.

Before Taking Your Medicine

Make sure you have told your doctor if you:

• are pregnant, planning to become pregnant or are breast feeding.


• are sensitive to piroxicam, aspirin, other NSAIDs, or any other ingredients in the capsules (have suffered from symptoms such as swelling, runny nose, difficulty breathing or itchy skin rash).


• have kidney or liver problems.


• have or have had a history of asthmatic attacks.


• have or have had a stomach or duodenal ulcer or gastrointestinal bleeding.


• have intestinal problems (eg ulcerative colitis, Crohn's disease).


• have heart problems or high blood pressure.


• are taking other medicines such as anticoagulants (eg warfarin), aspirin, diuretics (eg amiloride), cimetidine, lithium, other non-steroidal anti-inflammatory drugs (NSAIDs), drugs to treat high blood pressure (eg captopril and propranolol), drugs to treat heart conditions (eg digoxin), methotrexate, ciclosporin, corticosteroids (eg Prednisolone), antibacterial drugs such as norfloxacin, mifepristone (or within 8-12 days of taking mifepristone) and including any that you can buy without prescription.

Medicines such as piroxicam may be associated with a small increased risk of heart attack ("myocardial infarction") or stroke. Any risk is more likely with high doses and prolonged treatment. Do not exceed the recommended dose or duration of treatment.

If you have heart problems, previous stroke or think that you might be at risk of these conditions (for example if you have high blood pressure, diabetes or high cholesterol or are a smoker) you should discuss your treatment with your doctor or pharmacist.

Piroxicam may make you feel drowsy or dizzy, if so, do not drive a car or operate machinery.

Taking Your Medicine

Your doctor has decided the dose which is best for you. Always follow your doctor's instructions exactly, and those on the pharmacy label. If you do not understand anything, ask your doctor or pharmacist.

The usual dosage(s) are described below:

Age Group: Dosage

Adults (including elderly):

Arthritis & Ankylosing spondylitis: Initially 20mg as one dose, then 10-30mg daily (either as a single or divided dose).

Gout attack: Initially 40mg as one dose, then 40mg daily for 4-6 days (either as a single or a divided dose).

Sprains, strains, etc: Initially 40mg for 2 days (either as a single or divided dose), then 20mg daily for 5-12 days.

Children under 12 years: Not given to this age group.

These capsules should be taken as instructed - followed by a glass of water or milk. Continue to take them for as long as your doctor tells you to, it may be dangerous to stop without their advice.

If you forget to take a dose, take another as soon as you remember and then your next dose at the usual time. NEVER take two doses at the same time.

If you are elderly, it is particularly important to take this medicine exactly as directed by the doctor.

If you see another doctor or go into hospital, let them know what medicines you are taking.

If you accidentally take more than your prescribed dose, contact your nearest hospital casualty department, or tell your doctor, immediately.

After Taking Your Medicine

Like many medicines, piroxicam may occasionally cause side-effects in some patients, particularly when you first start taking it. These may include anxiety, dizziness, vertigo (a spinning sensation), tremor (shakiness of the arms or legs), difficulty in sleeping or nightmares, tiredness, irritability, loss of or abnormal sensations such as pins and needles, blurred or double vision, impaired hearing or ringing in the ears, headache, bitter taste or other taste change, mouth ulcers, swollen tongue, constipation, diarrhoea, feeling or being sick, loss of appetite, mild to moderate stomach discomfort or gas, loss of hair or finger and toenails, increased sensitivity to the effects of the sun (or sunlamps), skin rashes which may be raised, itchy, red, blister-like and severe, oedema (body swelling particularly of the ankles), nose bleeds. You should consult your doctor if these are troublesome or continue.

If you get visual disturbances, memory disturbance, mood or mental changes; convulsions (seizures); bloody stools; difficult, burning or painful urination; severe stomach pain, indigestion or heartburn for the first time; spitting up blood, unusual bleeding or bruising; persistent sore throat or high temperature; skin rash; allergic reactions such as wheezing or shortness of breath, swelling of the face and throat, swelling of blood vessels which may be associated with fever, rash and joint pains; very fast but irregular heartbeat or pulse; yellowing of the skin or eyes, or any other unusual effects, tell your doctor immediately and seek advice.

Medicines such as piroxicam may be associated with a small increased risk of heart attack ("myocardial infarction") or stroke.

Whilst you are taking piroxicam your doctor may want to give you a check-up from time to time.

Storing Your Medicine

Do not use the capsules after the expiry date shown on the product packaging. Keep the capsules below 25°C in a dry place and protected from light, and in the original packaging. KEEP THEM IN A SECURE PLACE WHERE CHILDREN CANNOT GET AT OR SEE THEM. REMEMBER, this medicine is for YOU only. NEVER give it to anyone else. It may harm them, even if their symptoms are the same as yours. Unless your doctor tells you to, do not keep medicines that you no longer need - give them back to your pharmacist for safe disposal.

Date of last revision: March 2007

Aloxi Capsules

Pronunciation: PAL-oh-NOE-se-tron
Generic Name: Palonosetron
Brand Name: Aloxi

Aloxi Capsules is used for:

Preventing nausea and vomiting caused by cancer chemotherapy. It may also be used for other conditions as determined by your doctor.

Aloxi Capsules is 5-HT₃ receptor blocker. It works by blocking the action of serotonin in certain parts of the brain and nervous system, which helps reduce or prevent nausea and vomiting.

Do NOT use Aloxi Capsules if:

• you are allergic to any ingredient in Aloxi Capsules


• you are taking apomorphine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aloxi Capsules:

Some medical conditions may interact with Aloxi Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are allergic to other 5-HT₃ receptor antagonists (eg, ondansetron)


• if you have a history of heart problems (eg, irregular heartbeat, prolonged QT), an abnormal heart function test (eg, electrocardiogram [ECG]), or low blood levels of potassium or magnesium

Some MEDICINES MAY INTERACT with Aloxi Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Apomorphine because side effects such as severely low blood pressure or loss of consciousness may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aloxi Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aloxi Capsules:

Use Aloxi Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Aloxi Capsules. Talk to your pharmacist if you have questions about this information.


• Take Aloxi Capsules by mouth with or without food.


• If you miss a dose of Aloxi Capsules, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Aloxi Capsules.

Important safety information:

• Aloxi Capsules may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Aloxi Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Aloxi Capsules should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aloxi Capsules while you are pregnant. It is not known if Aloxi Capsules is found in breast milk. Do not breast-feed while you are using Aloxi Capsules.

Possible side effects of Aloxi Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; headache; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; trouble urinating; unusual muscle movement.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Aloxi side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Aloxi Capsules:

Store Aloxi Capsules at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aloxi Capsules out of the reach of children and away from pets.

General information:

• If you have any questions about Aloxi Capsules, please talk with your doctor, pharmacist, or other health care provider.


• Aloxi Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Aloxi Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Aloxi resources

• Aloxi Side Effects (in more detail)
• Aloxi Use in Pregnancy & Breastfeeding
• Aloxi Drug Interactions
• Aloxi Support Group
• 0 Reviews for Aloxi - Add your own review/rating

Compare Aloxi with other medications

• Nausea/Vomiting, Chemotherapy Induced
• Nausea/Vomiting, Postoperative

Third generation cephalosporins

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Cephalosporins are a group of broad spectrum, semi-synthetic beta-lactam antibiotics derived from the mould Cephalosporium. They are divided into three groups: Cephalosporin N and C are chemically related to penicillins and Cephalosporin P a steroid antibiotic resembles fusidic acid.

The mechanism of action of cephalosporins is the same as penicillins. They interfere with bacterial cell wall synthesis.

Semisynthetic broad-spectrum cephalosporins have been produced by the addition of different side chains, to the Cephalosporin C nucleus.

They are classified according to the chronological order in which they were produced.

Third generation cephalosporins followed the second generation cephalosporins.

See also

Medical conditions associated with third generation cephalosporins:

• Bacteremia
• Bacterial Endocarditis Prevention
• Bacterial Infection
• Bladder Infection
• Bone infection
• Bronchitis
• Cesarean Section
• Chancroid
• CNS Infection
• Conjunctivitis
• Endocarditis
• Endometritis
• Epididymitis, Non-Specific
• Epididymitis, Sexually Transmitted
• Epiglottitis
• Febrile Neutropenia
• Gastroenteritis
• Gonococcal Infection, Disseminated
• Gonococcal Infection, Uncomplicated
• Intraabdominal Infection
• Joint Infection
• Kidney Infections
• Lyme Disease
• Lyme Disease, Arthritis
• Lyme Disease, Carditis
• Lyme Disease, Neurologic
• Melioidosis
• Meningitis
• Meningococcal Meningitis Prophylaxis
• Neurosyphilis
• Nosocomial Pneumonia
• Otitis Externa
• Otitis Media
• Pelvic Inflammatory Disease
• Peritonitis
• Pneumonia
• Pneumonia with Cystic Fibrosis
• Prostatitis
• Salmonella Gastroenteritis
• Sepsis
• Septicemia
• Shigellosis
• Sinusitis
• Skin and Structure Infection
• Skin Infection
• STD Prophylaxis
• Strep Throat
• Surgical Prophylaxis
• Syphilis, Early
• Tonsillitis/Pharyngitis
• Typhoid Fever
• Upper Respiratory Tract Infection
• Urinary Tract Infection

Drug List:

Cedax

Rocephin

Claforan

Vantin

Suprax

Omnicef

Omnicef-Omni-Pac

Spectracef

Cefizox

Cefobid

Ceptaz

Fortaz

Tazicef

Amitriptyline/Chlordiazepoxide

Pronunciation: am-ee-TRIP-tih-leen/klor-dye-az-e-POX-ide
Generic Name: Amitriptyline/Chlordiazepoxide
Brand Name: Limbitrol DS

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Amitriptyline/Chlordiazepoxide outweigh the risks.

Family and caregivers must closely watch patients who take Amitriptyline/Chlordiazepoxide. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Amitriptyline/Chlordiazepoxide is used for:

Treating moderate to severe depression with moderate to severe anxiety. It may also be used for other conditions as determined by your doctor.

Amitriptyline/Chlordiazepoxide is a combination tricyclic antidepressant and benzodiazepine. How tricyclic antidepressants improve depression symptoms is not fully known. They are thought to increase the activity of certain chemicals in the brain (norepinephrine, serotonin), which help improve mood. The benzodiazepine works in the brain to decrease anxiety.

Do NOT use Amitriptyline/Chlordiazepoxide if:

• you are allergic to any ingredient in Amitriptyline/Chlordiazepoxide, to other tricyclic antidepressants (eg, nortriptyline), or to other benzodiazepines (eg, diazepam)


• you have acute narrow-angle glaucoma, severe liver disease, or severe mental problems (psychosis)


• you have taken linezolid, methylene blue, or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine, selegiline) within the last 14 days


• you are taking cisapride, droperidol, an H₁ antagonist (eg, astemizole, terfenadine), a ketolide (eg, telithromycin), a macrolide (eg, erythromycin), mibefradil, pimozide, or sodium oxybate (GHB)


• you are recovering from a heart attack

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Before using Amitriptyline/Chlordiazepoxide:

Some medical conditions may interact with Amitriptyline/Chlordiazepoxide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of mental illness (eg, bipolar disorder, mania, manic-depression), or have considered or attempted suicide


• if you have a history of alcohol or other substance abuse or dependence, or you regularly drink 3 or more alcohol-containing drinks per day


• if you have an irregular heartbeat, heart disease, chest pain, liver or kidney problems, prostate problems, thyroid disease, lung or breathing problems (eg, chronic obstructive pulmonary disease [COPD]), muscle problems (eg, myasthenia gravis), glaucoma, or risk factors for glaucoma, or you are unable to urinate (urinary retention)


• if you have a history of seizures, epilepsy, or blood problems (eg, porphyria)

Some MEDICINES MAY INTERACT with Amitriptyline/Chlordiazepoxide. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Rifampin because it may decrease Amitriptyline/Chlordiazepoxide's effectiveness


• Linezolid, MAOIs (eg, phenelzine, selegiline), or methylene blue because they can cause serious, sometimes life-threatening, reactions


• Anticholinergics (eg, scopolamine), azole antifungals (eg, ketoconazole), bupropion, cimetidine, clozapine, disulfiram, fluconazole, nefazodone, omeprazole, phenothiazines (eg, chlorpromazine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin norepinephrine reuptake inhibitors (eg, duloxetine), sodium oxybate (GHB), terbinafine, or valproic acid because side effects such as blurred vision, difficult urination, drowsiness or sedation, dry mouth, or lightheadedness may occur


• Antiarrhythmics (eg, quinidine, propafenone), arsenic, cisapride, droperidol, H₁ antagonists (eg, astemizole, terfenadine), ketolides (eg, telithromycin), macrolides (eg, erythromycin), mibefradil, pimozide, or streptogramins (eg, quinupristin/dalfopristin) because the risk of serious side effects on the heart (eg, racing heartbeat, dizziness, fainting, life-threatening abnormal heartbeat leading to unconsciousness, lack of heartbeat) may be increased by Amitriptyline/Chlordiazepoxide


• Anticoagulants (eg, warfarin), carbamazepine, hydantoins (eg, phenytoin), thyroid medicines (eg, levothyroxine), or sympathomimetics (eg, albuterol, pseudoephedrine) because the risk of their side effects may be increased by Amitriptyline/Chlordiazepoxide


• Clonidine, guanethidine, or guanfacine because their effectiveness may be decreased by Amitriptyline/Chlordiazepoxide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Amitriptyline/Chlordiazepoxide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Amitriptyline/Chlordiazepoxide:

Use Amitriptyline/Chlordiazepoxide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Amitriptyline/Chlordiazepoxide comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Amitriptyline/Chlordiazepoxide refilled.


• Take Amitriptyline/Chlordiazepoxide by mouth with or without food.


• Do not eat grapefruit or drink grapefruit juice while you use Amitriptyline/Chlordiazepoxide.


• Continue to use Amitriptyline/Chlordiazepoxide even if you feel well. Do not miss any doses.


• Do not suddenly stop taking Amitriptyline/Chlordiazepoxide. Withdrawal symptoms may occur if you decrease your dose or suddenly stop taking it. Talk with your doctor about any changes to your dose.


• If you miss a dose of Amitriptyline/Chlordiazepoxide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Amitriptyline/Chlordiazepoxide.

Important safety information:

• Amitriptyline/Chlordiazepoxide may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Amitriptyline/Chlordiazepoxide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Amitriptyline/Chlordiazepoxide; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Amitriptyline/Chlordiazepoxide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Children, teenagers, and young adults who take Amitriptyline/Chlordiazepoxide may be at increased risk for suicidal thoughts or actions. Watch all patients who take Amitriptyline/Chlordiazepoxide closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• Diabetes patients - Amitriptyline/Chlordiazepoxide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Amitriptyline/Chlordiazepoxide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Amitriptyline/Chlordiazepoxide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Do not become overheated in hot weather or while you are being active; heatstroke may occur.


• If your symptoms do not get better within 4 weeks or if they get worse, check with your doctor.


• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can.


• Tell your doctor or dentist that you take Amitriptyline/Chlordiazepoxide before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including blood cell counts and liver function tests, may be performed while you use Amitriptyline/Chlordiazepoxide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use caution in the ELDERLY; they may be more sensitive to its effects, especially drowsiness, confusion, lightheadedness upon standing, rapid heartbeat, breathing problems, difficult urination, and constipation.


• Amitriptyline/Chlordiazepoxide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Amitriptyline/Chlordiazepoxide has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Amitriptyline/Chlordiazepoxide while you are pregnant. Amitriptyline/Chlordiazepoxide is found in the breast milk. Do not breast-feed while taking Amitriptyline/Chlordiazepoxide.

When used for long periods of time or at high doses, Amitriptyline/Chlordiazepoxide may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Amitriptyline/Chlordiazepoxide stops working well. Do not take more than prescribed.

Some people who use Amitriptyline/Chlordiazepoxide for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you stop taking Amitriptyline/Chlordiazepoxide suddenly, you may have WITHDRAWAL symptoms. These may include convulsions, tremor, stomach and muscle cramps, vomiting, or sweating.

Possible side effects of Amitriptyline/Chlordiazepoxide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; bloating; blurred vision; constipation; diarrhea; disturbed concentration; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea; restlessness; tiredness; upset stomach; vomiting; weakness; weight gain or loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; decreased sexual ability; decreased or increased urination; decreased coordination; delusions; disorientation; fast or irregular heartbeat; fainting; fever, chills, or persistent sore throat; hallucinations; involuntary movements of tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes accompanied by involuntary movements of the arms and legs; lightheadedness; mental or mood changes; numbness of an arm or leg; one-sided weakness; pounding in the chest; seizures; severe constipation; speech problems; sudden severe dizziness, headache, stomach pain, or vomiting; tremors; unusual bleeding or bruising; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Amitriptyline/Chlordiazepoxide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; enlarged pupils; fast or irregular heartbeat; fever; hallucinations; loss of consciousness; muscle stiffness; seizures; severe or persistent drowsiness or dizziness; slow reflexes; stupor; vomiting.

Proper storage of Amitriptyline/Chlordiazepoxide:

Store Amitriptyline/Chlordiazepoxide at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Amitriptyline/Chlordiazepoxide out of the reach of children and away from pets.

General information:

• If you have any questions about Amitriptyline/Chlordiazepoxide, please talk with your doctor, pharmacist, or other health care provider.


• Amitriptyline/Chlordiazepoxide is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• Do not use Amitriptyline/Chlordiazepoxide for other health conditions.


• If your symptoms do not improve or if they become worse, check with your doctor.


• If your symptoms do not improve after taking Amitriptyline/Chlordiazepoxide for 4 weeks, inform your doctor.


• If using Amitriptyline/Chlordiazepoxide for an extended period of time, obtain refills before your supply runs out.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Amitriptyline/Chlordiazepoxide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Amitriptyline/Chlordiazepoxide resources

• Amitriptyline/Chlordiazepoxide Side Effects (in more detail)
• Amitriptyline/Chlordiazepoxide Use in Pregnancy & Breastfeeding
• Drug Images
• Amitriptyline/Chlordiazepoxide Drug Interactions
• Amitriptyline/Chlordiazepoxide Support Group
• 7 Reviews for Amitriptyline/Chlordiazepoxide - Add your own review/rating

Compare Amitriptyline/Chlordiazepoxide with other medications

• Anxiety
• Depression

Loprox

Generic Name: ciclopirox topical (sye kloe PEER ox)

Brand Names: Loprox, Penlac Nail Lacquer

What is Loprox (ciclopirox topical)?

Ciclopirox is an antifungal medication. Ciclopirox topical prevents fungus from growing.

Ciclopirox topical cream and lotion formulations are used to treat skin infections such as athlete's foot, jock itch, ringworm, and yeast infections. Ciclopirox shampoo is used to treat seborrheic dermatitis (inflammatory skin condition) of the scalp. Ciclopirox topical nail lacquer is used to treat fungal infections of the toenails and fingernails.

Ciclopirox topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Loprox (ciclopirox topical)?

Avoid getting ciclopirox topical in the eyes, nose, or mouth. Do not use bandages or dressings that do not allow air to circulate (occlusive dressings) on areas treated with ciclopirox cream or lotion, unless otherwise directed by your doctor. Wear loose-fitting clothing (preferably cotton).

Use ciclopirox topical nail lacquer on nails and immediately surrounding skin only.

Ciclopirox topical nail lacquer is flammable, keep it away from heat and flame.

Use ciclopirox topical for the full amount of time prescribed by your doctor. Your symptoms may improve before the infection is completely healed however, it is important to use the medication for the full amount of time.

What should I discuss with my healthcare provider before using Loprox (ciclopirox topical)?

Do not use ciclopirox topical if you have had an allergic reaction to it in the past.

Before using ciclopirox topical, tell your doctor if you

• 
  

  have diabetes;

  
  


• 
  

  are immunosuppressed (e.g., have received an organ transplant or have AIDS);

  
  


• 
  

  take medication to control epilepsy or another seizure disorder;

  
  


• 
  

  use a topical corticosteroid on a regular basis; or

  
  


• 
  

  use a steroid inhaler on a regular basis.

  
  

You may not be able to use ciclopirox topical nail lacquer or you may require a dosage adjustment or special monitoring during your treatment .

Ciclopirox topical is the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use ciclopirox topical without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether ciclopirox passes into breast milk. Do not use ciclopirox topical without first talking to your doctor if you are breast-feeding a baby.

How should I use Loprox (ciclopirox topical)?

Use ciclopirox topical exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

To use ciclopirox topical cream or lotion:

• 
  

  Wash your hands before and after using this medication, unless you are using ciclopirox topical to treat a hand condition.

  
  


• 
  

  Clean and dry the affected area. Apply a small amount of the cream (usually twice daily) for 2 to 4 weeks. Follow your doctor's instructions.

  
  


• Do not use bandages or dressings that do not allow air to circulate (occlusive dressings) on areas treated with ciclopirox cream or lotion, unless otherwise directed by your doctor. Wear loose-fitting clothing (preferably cotton).


• 
  

  If the infection does not clear up in 4 weeks, or if it appears to get worse, see your doctor.

  
  

To use ciclopirox shampoo:

• 
  

  Wet the hair and apply approximately 1 teaspoon (5 mL) of the shampoo to the scalp. Up to 2 teaspoons (10 mL) may be used for long hair. Lather and leave on the hair and scalp for 3 minutes. A timer may be used. Rinse off the shampoo after 3 minutes have passed.

  
  


• 
  

  Avoid contact with the eyes, nose, and inside of the mouth.

  
  


• 
  

  Treatment should be repeated twice per week for 4 weeks, with a minimum of 3 days between applications. If no improvement is seen after 4 weeks of treatment, contact your doctor.

  
  

To use ciclopirox topical nail lacquer:

• 
  

  Remove any loose nail or nail material using nail clippers or a nail file.

  
  


• 
  

  Apply ciclopirox topical nail lacquer once daily (preferably at bedtime) to all affected nails with the applicator brush provided. Apply the lacquer evenly over the entire nail. Where possible, apply the nail laquer to the underside of the nail and to the skin beneath it. Allow the lacquer to dry (approximately 30 seconds) before putting on socks or stockings. After applying the medication, wait 8 hours before taking a bath or shower.

  
  


• 
  

  Apply ciclopirox topical nail lacquer daily over the previous coat. Once a week, remove ciclopirox topical nail lacquer with alcohol. Remove as much as possible of the damaged nail using nail clippers or nail a file.

  
  


• 
  

  Use ciclopirox topical nail lacquer on nails and immediately surrounding skin only. Avoid contact with other areas.

  
  


• 
  

  Treatment with ciclopirox topical nail lacquer may require six months or more before initial improvement of symptoms is noticed. Up to 48 weeks of daily application of the nail lacquer, monthly removal of the unattached infected nail by a health care professional, and weekly trimming by the patient may be required for complete treatment.

  
  


• 
  

  To prevent the screw cap from sticking to the bottle, do not allow the solution to get into the bottle treads. To prevent the solution from drying out, close the bottle tightly after every use.

  
  

Use ciclopirox topical for the full amount of time prescribed by your doctor. Your symptoms may improve before the infection is completely healed however, it is important to use the medication for the full amount of time. Avoid getting ciclopirox topical in the eyes, nose, or mouth. Store ciclopirox topical at room temperature away from moisture and heat. Ciclopirox topical nail lacquer is flammable, keep it away from heat and flame. Protect the ciclopirox topical nail lacquer from light by storing the bottle in the carton after every use. Once a bottle of ciclopirox topical shampoo is opened, it should be used within 8 weeks.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the dose you missed and apply only the regular amount of ciclopirox topical. Do not use a double dose unless otherwise directed by your doctor.

What happens if I overdose?

An overdose of ciclopirox topical is unlikely to occur. If you do suspect that a much larger than normal dose has been used or that ciclopirox topical has been ingested, contact an emergency room or a poison control center.

What should I avoid while using Loprox (ciclopirox topical)?

Avoid wearing tight-fitting, synthetic clothing that doesn't allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Do not use nail polish, artificial nails, or other cosmetic nail products on the nails treated with ciclopirox topical nail lacquer.

Loprox (ciclopirox topical) side effects

Serious side effects of ciclopirox topical use are not expected to occur. Stop using ciclopirox topical and contact your doctor if you experience unusual or severe itching, redness, burning, dryness, or irritation of the skin or discoloration or other changes in the nails.

Mild burning, itching, or redness may occur with use of ciclopirox topical shampoo.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Loprox (ciclopirox topical)?

Avoid using other topical products at the same time unless directed otherwise by your doctor. Other skin medications may affect the absorption or effectiveness of ciclopirox topical formulations.

Do not use nail polish, artificial nails, or other cosmetic nail products on the nails treated with ciclopirox topical nail lacquer.

Drugs other than those listed here may also interact with ciclopirox topical. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines, including herbal products.

More Loprox resources

• Loprox Side Effects (in more detail)
• Loprox Use in Pregnancy & Breastfeeding
• Loprox Support Group
• 2 Reviews for Loprox - Add your own review/rating

• Loprox Prescribing Information (FDA)


• Loprox Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Loprox Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Ciclodan Prescribing Information (FDA)

Compare Loprox with other medications

• Cutaneous Candidiasis
• Seborrheic Dermatitis
• Tinea Corporis
• Tinea Cruris
• Tinea Pedis
• Tinea Versicolor

Where can I get more information?

• Your pharmacist has additional information about ciclopirox topical written for health professionals that you may read.

See also: Loprox side effects (in more detail)

Integrobe

Integrobe may be available in the countries listed below.

Ingredient matches for Integrobe

Metamizole

Metamizole is reported as an ingredient of Integrobe in the following countries:

• Argentina

International Drug Name Search

lodoxamide ophthalmic

Generic Name: lodoxamide ophthalmic (loe DOX a mide)

Brand Names: Alomide

What is lodoxamide ophthalmic?

Lodoxamide is an allergy medication. It inhibits processes in the body that cause allergic symptoms in response to allergy-causing substances.

Lodoxamide ophthalmic (for the eyes) is used to treat seasonal eye symptoms such as inflammation, itching, redness, and burning.

Lodoxamide ophthalmic may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about lodoxamide ophthalmic?

Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use lodoxamide while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses and cause discoloration. Wait at least 15 minutes after using lodoxamide before putting your contact lenses in. Stop using lodoxamide and call your doctor at once if you have severe burning or stinging when you apply the eye drops, or for long periods of time after using the drops.

What should I discuss with my healthcare provider before using lodoxamide ophthalmic?

You should not use this medication if you are allergic to lodoxamide. FDA pregnancy category B. Lodoxamide is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether lodoxamide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use lodoxamide ophthalmic?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Do not use lodoxamide while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses and cause discoloration. Wait at least 15 minutes after using lodoxamide before putting your contact lenses in. Wash your hands before using the eye drops.

To apply the eye drops:

• 
  

  Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.

  
  


• 
  

  Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.

  
  


• 
  

  Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

  
  

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

Store the drops at cool room temperature away from heat and moisture. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of lodoxamide ophthalmic applied to the eyes is not likely to occur.

What should I avoid while using lodoxamide ophthalmic?

Do not touch the dropper to any surface, including your eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye.

Do not use any other eye medications unless your doctor has prescribed them.

Lodoxamide ophthalmic side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using lodoxamide and call your doctor at once if you have severe burning or stinging when you apply the eye drops, or for long periods of time after using the drops.

Less serious side effects may include:

• 
  

  mild burning, stinging, or eye irritation;

  
  


• 
  

  eye itching, watering, pain, or redness;

  
  


• 
  

  blurred vision;

  
  


• 
  

  dry eyes;

  
  


• 
  

  swollen or puffy eye lids;

  
  


• 
  

  feeling that something is in your eye; or

  
  


• 
  

  crusting or drainage from your eyes.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Lodoxamide ophthalmic Dosing Information

Usual Adult Dose for Keratitis:

1 or 2 drops in each affected eye four times daily. Therapy may be continued for up to 3 months.

Usual Adult Dose for Keratoconjunctivitis:

1 or 2 drops in each affected eye four times daily. Therapy may be continued for up to 3 months.

Usual Adult Dose for Conjunctivitis:

1 or 2 drops in each affected eye four times daily. Therapy may be continued for up to 3 months.

Usual Pediatric Dose for Keratitis:

2 to 18 years: 1 or 2 drops in each affected eye four times daily. Therapy may be continued for up to 3 months.

Usual Pediatric Dose for Keratoconjunctivitis:

2 to 18 years: 1 or 2 drops in each affected eye four times daily. Therapy may be continued for up to 3 months.

Usual Pediatric Dose for Conjunctivitis:

2 to 18 years: 1 or 2 drops in each affected eye four times daily. Therapy may be continued for up to 3 months.

What other drugs will affect lodoxamide ophthalmic?

It is not likely that other drugs you take orally or inject will have an effect on lodoxamide ophthalmic. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More lodoxamide ophthalmic resources

• Lodoxamide ophthalmic Side Effects (in more detail)
• Lodoxamide ophthalmic Dosage
• Lodoxamide ophthalmic Use in Pregnancy & Breastfeeding
• Lodoxamide ophthalmic Support Group
• 0 Reviews for Lodoxamide - Add your own review/rating

• Alomide Prescribing Information (FDA)


• Alomide Monograph (AHFS DI)


• Alomide Advanced Consumer (Micromedex) - Includes Dosage Information


• Alomide MedFacts Consumer Leaflet (Wolters Kluwer)

Compare lodoxamide ophthalmic with other medications

• Conjunctivitis
• Keratitis
• Keratoconjunctivitis

Where can I get more information?

• Your pharmacist can provide more information about lodoxamide ophthalmic.

See also: lodoxamide side effects (in more detail)

Avandia

Generic Name: rosiglitazone (Oral route)

roe-zi-GLI-ta-zone

Oral route(Tablet)

May cause or worsen congestive heart failure, is not recommended in patients with symptomatic heart failure, and is contraindicated in patients with established NYHA Class III or IV heart failure. Monitor patients for signs and symptoms of heart failure after initiation or dose increases and if heart failure occurs, consider dose reducing or discontinuing rosiglitazone maleate and manage according to current standards of care. A meta-analysis of 52 clinical trials (mean duration 6 months; 16,995 total patients), most of which compared rosiglitazone to placebo, showed rosiglitazone to be associated with a statistically significant increased risk of myocardial infarction. Because of the potential increased risk of myocardial infarction, rosiglitazone maleate is available only through a restricted distribution program called the AVANDIA-Rosiglitazone Medicines Access Program. Both prescribers and patients need to enroll in the program. To enroll, call 1-800-AVANDIA or visit www.AVANDIA.com .

Commonly used brand name(s)

In the U.S.

• Avandia

Available Dosage Forms:

• Tablet

Therapeutic Class: Antidiabetic

Chemical Class: Thiazolidinedione

Uses For Avandia

Rosiglitazone is used to treat a type of diabetes mellitus called type 2 diabetes. It may be used alone or with other medicines such as metformin or sulfonylurea agents. Rosiglitazone is used together with a proper diet and exercise to help control blood sugar levels. It does this by helping your body use insulin better.

This medicine is only available through a restricted access program. Doctors who are enrolled in the program can write a prescription for this medicine.

Before Using Avandia

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of rosiglitazone in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rosiglitazone in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Bitter Melon


• Fenofibrate


• Fenugreek


• Gemfibrozil


• Glucomannan


• Guar Gum


• Psyllium


• Rifampin


• Trimethoprim

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina, severe and acute or


• Diabetic ketoacidosis (ketones in the blood) or


• Heart attack, acute or


• Heart failure, severe or with symptoms or


• Type 1 diabetes—Should not be used in patients with these conditions.

• Diabetic macular edema (swelling of the back of the eye) or


• Edema (fluid retention or swelling) or


• Heart attack, history of or


• Heart disease, history of or


• Liver disease—Use with caution. May make these conditions worse.

• Fever or


• Infection or


• Surgery or


• Trauma—Use with caution. These conditions may cause problems with blood sugar control.

• Fragile bones (especially in women)—Use with caution. This medicine may increase the risk for fractures.

Proper Use of Avandia

Take this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

Carefully follow the special diet your doctor gave you. This is the most important part of controlling your diabetes and will help the medicine work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

This medicine is only available through a restricted access program. Both you and your doctor must enroll in this program. You might have to sign a consent form in order to receive this medicine and your doctor will closely monitor your progress while you are taking this medicine. Talk to your doctor if you have questions about this.

This medicine should come with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

This medicine may be taken with or without food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For type 2 diabetes:
    
    • Adults—At first, 4 milligrams (mg) per day, taken as a single dose or divided into two doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 8 mg per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Avandia

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Call your doctor right away if you have chest pain or discomfort; nausea; pain or discomfort in the arms, jaw, back, or neck; shortness of breath; sweating; or vomiting. These may be symptoms of a heart attack.

If you are rapidly gaining weight or having shortness of breath, chest pain or discomfort, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor right away. These may be symptoms of a heart problem or edema (fluid retention).

If you have abdominal or stomach pain; dark urine; a loss of appetite; nausea or vomiting; unusual tiredness or weakness; or yellow eyes or skin, check with your doctor right away. These may be symptoms of a serious liver problem.

Check with your doctor right away if blurred vision, difficulty in reading, or any other change in vision occurs while you are taking this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

This medicine may increase the risk for bone fractures in women. Ask your doctor about ways to keep your bones strong to help prevent fractures.

Certain women may be at an increased risk for pregnancy while taking this medicine. If you had problems ovulating and had irregular periods in the past, this medicine may cause you to ovulate. This could increase your chance of becoming pregnant. If you are a woman of childbearing potential, you should discuss birth control options with your doctor.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

It is very important to carefully follow any instructions from your doctor about:

• Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your doctor.


• Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.


• Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, diabetic patients may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy.


• Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times.


• In case of emergency—There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says that you have diabetes and a list of all of your medicines.


• Symptoms of fluid retention—Know what to do if you start to retain fluid. Fluid retention may worsen or lead to heart problems.

This medicine does not cause hypoglycemia (low blood sugar). However, low blood sugar can occur if you delay or miss a meal or snack, exercise more than usual, drink alcohol, cannot eat because of nausea or vomiting, or take rosiglitazone with another type of diabetes medicine. The symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people feel different symptoms of low blood sugar. It is important that you learn which symptoms of low blood sugar you usually have so that you can treat it quickly.

• Symptoms of low blood sugar include anxiety; behavior change similar to being drunk; blurred vision; cold sweats; confusion; cool, pale skin; difficulty in thinking; drowsiness; excessive hunger; fast heartbeat; headache (continuing); nausea; nervousness; nightmares; restless sleep; shakiness; slurred speech; or unusual tiredness or weakness.


• If symptoms of low blood sugar occur, eat glucose tablets or gel, corn syrup, honey, or sugar cubes; or drink fruit juice, non-diet soft drinks, or sugar dissolved in water to relieve the symptoms. Also, check your blood for low blood sugar. Glucagon is used in emergency situations when severe symptoms such as seizures (convulsions) or unconsciousness occur. Have a glucagon kit available, along with a syringe and needle, and know how to use it. Members of your family also should know how to use it.

Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual.

• Symptoms of high blood sugar include blurred vision; drowsiness; dry mouth; flushed, dry skin; fruit-like breath odor; increased urination (frequency and amount); ketones in the urine; loss of appetite; sleepiness; stomachache, nausea, or vomiting; tiredness; troubled breathing (rapid and deep); unconsciousness; or unusual thirst.


• If the symptoms of high blood sugar occur, check your blood sugar level and call your doctor for instructions.

Avandia Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Abdominal or stomach pain


• blurred vision


• chest pain or discomfort


• decrease in the amount of urine


• dry mouth


• flushed, dry skin


• fruit-like breath odor


• increased hunger


• increased thirst


• increased urination


• irregular heartbeat


• nausea


• noisy, rattling breathing


• pain in the shoulders, arms, jaw, or neck


• pale skin


• shortness of breath


• sweating


• swelling of the fingers, hands, feet, or lower legs


• trouble breathing


• unexplained weight loss


• unusual bleeding or bruising


• unusual tiredness or weakness


• vomiting


• weight gain, rapid or unusual

Rare

• Anxiety


• chills


• cold sweats


• coma


• confusion


• dark urine


• depression


• dizziness


• fast heartbeat


• headache


• loss of appetite


• nervousness


• nightmares


• seizures


• shakiness


• slurred speech

Incidence not known

• Blue lips and fingernails


• changes in vision


• coughing that sometimes produces a pink frothy sputum


• hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• itching


• light-colored stools


• redness of the skin


• skin rash


• wheezing


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Ear congestion


• fever


• general feeling of discomfort or illness


• hoarseness or other voice changes


• injury


• joint pain


• muscle aches and pains


• runny or stuffy nose


• shivering


• sneezing


• sore throat


• trouble with sleeping

Less common

• Back pain


• cough


• diarrhea


• lightheadedness


• pain or tenderness around the eyes and cheekbones

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Avandia side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Avandia resources

• Avandia Side Effects (in more detail)
• Avandia Dosage
• Avandia Use in Pregnancy & Breastfeeding
• Drug Images
• Avandia Drug Interactions
• Avandia Support Group
• 7 Reviews for Avandia - Add your own review/rating

• Avandia Prescribing Information (FDA)


• Avandia Consumer Overview


• Avandia Monograph (AHFS DI)


• Avandia MedFacts Consumer Leaflet (Wolters Kluwer)


• Rosiglitazone Prescribing Information (FDA)

Compare Avandia with other medications

• Diabetes, Type 2
• Nonalcoholic Fatty Liver Disease

Moniliformis Infection Medications

Drugs associated with Moniliformis Infection

The following drugs and medications are in some way related to, or used in the treatment of Moniliformis Infection. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Drug List:

Antiminth

Ascarel

Pin-X-Chewable-Tablets

Pinworm-Caplets

Pinworm-Medicine

Reese-S-Pinworm-Medicine

Accolate

Generic Name: zafirlukast (Oral route)

za-fir-LOO-kast

Commonly used brand name(s)

In the U.S.

• Accolate

Available Dosage Forms:

• Tablet

Therapeutic Class: Anti-Inflammatory

Pharmacologic Class: Leukotriene Pathway Inhibitor

Uses For Accolate

Zafirlukast is used to help control the symptoms of asthma and improve lung function. However, this medicine should not be used to relieve an asthma attack that has already started.

This medicine is available only with your doctor's prescription.

Before Using Accolate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of zafirlukast in children. However, safety and efficacy have not been established in children younger than 5 years of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of zafirlukast in the elderly. However, elderly patients are more likely to have lower respiratory tract infections and unwanted side effects, which may require caution and an adjustment in the dose for elderly patients receiving zafirlukast.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Erythromycin


• Terfenadine


• Theophylline


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Asthma attack, acute—Should not be used to control acute asthma.

• Churg-Strauss syndrome (a rare blood condition)—Use with caution. May make this condition worse.

• Liver disease (including cirrhosis)—Should not be used in patients with this condition.

Proper Use of Accolate

Zafirlukast is used to prevent asthma attacks. It is not used to relieve an attack that has already started. For relief of an asthma attack that has already started, you should use an inhaled medicine that works quickly. If you do not have another medicine to use for an attack or if you have any questions about this, check with your doctor.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. Also, do not stop taking this medicine without telling your doctor. To do so may increase the chance of side effects.

This medicine usually comes with patient information leaflet. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Food may change the amount of zafirlukast that is absorbed. It should be taken on an empty stomach, 1 hour before or 2 hours after a meal.

To work properly, zafirlukast must be taken every day at regularly spaced times, even if your asthma seems better.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For asthma:
    
    • Adults and children 12 years of age and older—20 milligrams (mg) two times a day.
    
    
    • Children 5 to 11 years of age—10 mg two times a day.
    
    
    • Children younger than 5 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Accolate

It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

You or your child may be taking other medicines for asthma along with zafirlukast. Do not stop taking or reduce the dose of the other medicines, even if your asthma seems better, unless you are told to do so by your doctor.

Check with your doctor if your or your child's symptoms do not improve or if your asthma gets worse.

Stop using this medicine and check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause a rare blood condition called Churg-Strauss syndrome. This usually occurs in patients who have asthma or are taking oral steroid medicines that is being stopped or the dose is being reduced or lowered. Tell your doctor right away if you or your child have the following symptoms: a feeling of pins and needles, flu-like symptoms, numbness of the arms or legs, rash, or pain and swelling of the sinuses.

This medicine may cause some people to be agitated, disoriented, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed and have problems with sleep. If you, your child, or your caregiver notice any of these side effects, tell your doctor or your child's doctor right away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Accolate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Cough or hoarseness


• fever or chills


• lower back or side pain


• pain


• painful or difficult urination

Rare

• Abdominal or stomach pain


• clay-colored stools


• dark urine


• diarrhea


• dizziness


• headache


• itching


• loss of appetite


• nausea


• rash


• unpleasant breath odor


• unusual tiredness or weakness


• vomiting of blood


• yellow eyes or skin

Incidence not known

• Attack, assault, or force


• attempts at killing oneself


• discouragement


• dry mouth


• fear or nervousness


• feeling sad or empty


• fever with or without chills


• general feeling of tiredness or weakness


• hyperventilation


• irregular heartbeats


• irritability


• lack of appetite


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• loss of interest or pleasure


• restlessness


• seeing, hearing, or feeling things that are not there


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• sleeplessness


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• tiredness


• trembling or shaking of the hands or feet


• trouble with concentrating


• trouble with sleeping


• unable to sleep


• unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Acid or sour stomach


• back pain


• belching


• difficulty with moving


• heartburn


• indigestion


• joint pain


• lack or loss of strength


• muscle aching or cramping


• muscle pains or stiffness


• stomach discomfort or upset


• swollen joints


• vomiting

Incidence not known

• Hives or welts


• redness of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Accolate side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Accolate resources

• Accolate Side Effects (in more detail)
• Accolate Use in Pregnancy & Breastfeeding
• Drug Images
• Accolate Drug Interactions
• Accolate Support Group
• 3 Reviews for Accolate - Add your own review/rating

• Accolate Prescribing Information (FDA)


• Accolate MedFacts Consumer Leaflet (Wolters Kluwer)


• Accolate Concise Consumer Information (Cerner Multum)


• Accolate Monograph (AHFS DI)


• Zafirlukast Prescribing Information (FDA)


• Zafirlukast Professional Patient Advice (Wolters Kluwer)

Compare Accolate with other medications

• Asthma, Maintenance

antidepressant, monoamine oxidase (mao) inhibitor Oral

Class Name: antidepressant, monoamine oxidase (MAO) INHIBITOR (Oral route)

Commonly used brand name(s):

In the U.S.

• Azilect


• Eldepryl


• Marplan


• Nardil


• Parnate


• Zelapar

Available Dosage Forms:

• Tablet


• Capsule


• Tablet, Disintegrating

Uses For This Medicine

Monoamine oxidase (MAO) inhibitors are used to relieve certain types of mental depression. They work by blocking the action of a chemical substance known as monoamine oxidase (MAO) in the nervous system.

Although these medicines are very effective for certain patients, they may also cause some unwanted reactions if not taken in the right way. It is very important to avoid certain foods, beverages, and medicines while you are being treated with an MAO inhibitor. Your health care professional will help you obtain a list to carry in your wallet or purse as a reminder of which products you should avoid.

These medicines are available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, phenelzine and tranylcypromine are used in certain patients with the following medical conditions:

• Headache


• Panic disorder

Importance of Diet

Dangerous reactions such as sudden high blood pressure may result when MAO inhibitors are taken with certain foods or drinks. The following foods should be avoided:

• Foods that have a high tyramine content (most common in foods that are aged or fermented to increase their flavor), such as cheeses; fava or broad bean pods; yeast or meat extracts; smoked or pickled meat, poultry, or fish; fermented sausage (bologna, pepperoni, salami, summer sausage) or other fermented meat; sauerkraut; or any overripe fruit. If a list of these foods and beverages is not given to you, ask your health care professional to provide one.


• Alcoholic beverages or alcohol-free or reduced-alcohol beer and wine.


• Large amounts of caffeine-containing food or beverages such as coffee, tea, cola, or chocolate.

Before Using This Medicine

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Antidepressants must be used with caution in children, teenagers, and young adults with depression. Studies have shown occurrences of children, teenagers, and young adults thinking about suicide or attempting suicide in clinical trials for this medicine. More study is needed to be sure antidepressants are safe and effective in children, teenagers, and young adults .

Animal studies have shown that these medicines may slow growth in the young. Therefore, be sure to discuss with your doctor the use of these medicines in children.

Geriatric

Dizziness or lightheadedness may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to these effects of MAO inhibitors.

Pregnancy

A limited study in pregnant women showed an increased risk of birth defects when these medicines were taken during the first 3 months of pregnancy. In animal studies, MAO inhibitors caused a slowing of growth and increased excitability in the newborn when very large doses were given to the mother during pregnancy.

Breast Feeding

Tranylcypromine passes into the breast milk; it is not known whether isocarboxazid or phenelzine passes into breast milk. Problems in nursing babies have not been reported.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

• Amitriptyline


• Amoxapine


• Amphetamine


• Apraclonidine


• Atomoxetine


• Benzphetamine


• Brimonidine


• Bupropion


• Buspirone


• Carbamazepine


• Citalopram


• Clomipramine


• Clovoxamine


• Cocaine


• Cyclobenzaprine


• Cyproheptadine


• Desipramine


• Desvenlafaxine


• Dexfenfluramine


• Dexmethylphenidate


• Dextroamphetamine


• Dextromethorphan


• Diethylpropion


• Dobutamine


• Dopamine


• Dothiepin


• Doxepin


• Duloxetine


• Ephedrine


• Epinephrine


• Escitalopram


• Femoxetine


• Fenfluramine


• Fluoxetine


• Fluvoxamine


• Furazolidone


• Guanadrel


• Guanethidine


• Imipramine


• Isocarboxazid


• Isometheptene


• Isoproterenol


• Levodopa


• Levomethadyl


• Linezolid


• Lisdexamfetamine


• Lofepramine


• Maprotiline


• Mazindol


• Meperidine


• Mephentermine


• Metaraminol


• Methadone


• Methamphetamine


• Methotrimeprazine


• Methoxamine


• Methyldopa


• Methylphenidate


• Milnacipran


• Mirtazapine


• Morphine


• Morphine Sulfate Liposome


• Nefazodone


• Nefopam


• Norepinephrine


• Nortriptyline


• Opipramol


• Oxcarbazepine


• Pargyline


• Paroxetine


• Phendimetrazine


• Phenelzine


• Phenmetrazine


• Phentermine


• Phenylalanine


• Phenylephrine


• Phenylpropanolamine


• Procarbazine


• Propoxyphene


• Protriptyline


• Pseudoephedrine


• Rasagiline


• Reserpine


• Rizatriptan


• Selegiline


• Sertraline


• Sibutramine


• St John's Wort


• Sumatriptan


• Tapentadol


• Tetrabenazine


• Tramadol


• Tranylcypromine


• Trimipramine


• Tryptophan


• Venlafaxine


• Zolmitriptan

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Albuterol


• Altretamine


• Amitriptyline


• Amoxapine


• Arformoterol


• Avocado


• Bambuterol


• Bitolterol


• Bitter Orange


• Broxaterol


• Buspirone


• Citalopram


• Clenbuterol


• Clomipramine


• Clovoxamine


• Desipramine


• Difenoxin


• Diphenoxylate


• Disulfiram


• Dopamine


• Dothiepin


• Doxepin


• Droperidol


• Entacapone


• Ephedrine


• Epinephrine


• Escitalopram


• Ethchlorvynol


• Femoxetine


• Fenoterol


• Fentanyl


• Fluoxetine


• Fluvoxamine


• Formoterol


• Guarana


• Hexoprenaline


• Hydromorphone


• Imipramine


• Isoetharine


• Kava


• Levalbuterol


• Levodopa


• Licorice


• Lithium


• Lofepramine


• Ma Huang


• Maprotiline


• Mate


• Mephentermine


• Metaraminol


• Methoxamine


• Metoclopramide


• Nefazodone


• Nortriptyline


• Oxycodone


• Paroxetine


• Pentazocine


• Phenylephrine


• Pirbuterol


• Procaterol


• Protriptyline


• Reboxetine


• Rimiterol


• Ritodrine


• Salmeterol


• Sertraline


• Sibutramine


• St John's Wort


• Sumatriptan


• Terbutaline


• Tolcapone


• Tramadol


• Trimipramine


• Tryptophan


• Tulobuterol


• Tyrosine


• Venlafaxine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using medicines in this class with any of the following is not recommended. Your doctor may decide not to treat you with a medication in this class, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco.

• Caffeine


• Dopamine Containing Food


• Tyramine Containing Food

Using medicines in this class with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use your medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Tyramine Containing Food

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse—Drinking alcohol while you are taking an MAO inhibitor may cause serious side effects.

• Angina (chest pain) or


• Headaches (severe or frequent)—These conditions may interfere with warning signs of serious side effects of MAO inhibitors.

• Asthma or bronchitis—Some medicines used to treat these conditions may cause serious side effects when used while you are taking an MAO inhibitor.

• Diabetes mellitus (sugar diabetes)—These medicines may change the amount of insulin or oral antidiabetic medication that you need.

• Epilepsy—Seizures may occur more often.

• Heart or blood vessel disease or


• Liver disease or


• Mental illness (or history of) or


• Parkinson's disease or


• Recent heart attack or stroke—MAO inhibitors may make the condition worse.

• High blood pressure—Condition may be affected by these medicines.

• Kidney disease—Higher blood levels of MAO inhibitors may occur, which increases the chance of side effects.

• Overactive thyroid or


• Pheochromocytoma (PCC)—Serious side effects may occur.

Proper Use of This Medicine

Sometimes this medicine must be taken for several weeks before you begin to feel better. Your doctor should check your progress at regular visits, especially during the first few months of treatment, to make sure that this medicine is working properly and to check for unwanted effects.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

MAO inhibitors may be taken with or without food or on a full or empty stomach. However, if your doctor tells you to take the medicine a certain way, take it exactly as directed.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For isocarboxazid


• For oral dosage form (tablets):
  
  • For treatment of depression:
    
    • Adults—To start, 10 milligrams (mg) twice a day. Your doctor may increase your dose gradually as needed. However, the dose usually is not more than 60 mg a day.
    
    
    • Children younger than 16 years of age—Use and dose must be determined by the doctor.
    
    
  
  

• For phenelzine


• For oral dosage form (tablets):
  
  • For treatment of depression:
    
    • Adults—Dose is based on your body weight. To start, the usual dose is 1 milligram (mg) per kilogram (kg) of body weight (0.45 mg per pound) a day. Your doctor may decrease or increase your dose as needed. However, the dose usually is not more than 90 mg a day.
    
    
    • Children younger than 16 years of age—Use and dose must be determined by the doctor.
    
    
    • Older adults—To start, 15 mg in the morning. Your doctor may increase your dose gradually as needed. However, the dose usually is not more than 60 mg a day.
    
    
  
  

• For tranylcypromine


• For oral dosage form (tablets):
  
  • For treatment of depression:
    
    • Adults—To start, 30 milligrams (mg) a day. Your doctor may increase your dose gradually as needed. However, the dose usually is not more than 60 mg a day.
    
    
    • Children younger than 16 years of age—Use and dose must be determined by the doctor.
    
    
    • Older adults—To start, 2.5 to 5 mg a day. The doctor may increase your dose as needed. However, the dose usually is not more than 45 mg a day.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of this medicine, take it as soon as possible. However, if it is within 2 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using This Medicine

When taken with certain foods, drinks, or other medicines, MAO inhibitors can cause very dangerous reactions such as sudden high blood pressure (also called hypertensive crisis). To avoid such reactions, obey the following rules of caution:

• Do not eat foods that have a high tyramine content (most common in foods that are aged or fermented to increase their flavor), such as cheeses; fava or broad bean pods; yeast or meat extracts; smoked or pickled meat, poultry, or fish; fermented sausage (bologna, pepperoni, salami, and summer sausage) or other fermented meat; sauerkraut; or any overripe fruit. If a list of these foods is not given to you, ask your health care professional to provide one.


• Do not drink alcoholic beverages or alcohol-free or reduced-alcohol beer and wine.


• Do not eat or drink large amounts of caffeine-containing food or beverages such as coffee, tea, cola, or chocolate.


• Do not take any other medicine unless approved or prescribed by your doctor. This especially includes nonprescription (over-the-counter [OTC]) medicine, such as that for colds (including nose drops or sprays), cough, asthma, hay fever, and appetite control; “keep awake'' products; or products that make you sleepy.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Check with your doctor or hospital emergency room immediately if severe headache, stiff neck, chest pains, fast heartbeat, or nausea and vomiting occur while you are taking this medicine. These may be symptoms of a serious side effect that should have a doctor's attention.

Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are using before stopping completely.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. When you get up from lying down, sit on the edge of the bed with your feet dangling for 1 or 2 minutes. Then stand up slowly. If the problem continues or gets worse, check with your doctor.

This medicine may cause blurred vision or make some people drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are unable to see well or are not alert.

Antidepressants may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away.

Before having any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine or have used it within the past 2 weeks. Taking MAO inhibitors together with medicines that are used during surgery or dental or emergency treatments may increase the risk of serious side effects.

Your doctor may want you to carry an identification card stating that you are using this medicine.

For patients with angina (chest pain):

• This medicine may cause you to have an unusual feeling of good health and energy. However, do not suddenly increase the amount of exercise you get without discussing it with your doctor. Too much activity could bring on an attack of angina.

For diabetic patients:

• This medicine may affect blood sugar levels. While you are using this medicine, be especially careful in testing for sugar in your blood or urine. If you have any questions about this, check with your doctor.

After you stop using this medicine, you must continue to obey the rules of caution for at least 2 weeks concerning food, drink, and other medicine, since these things may continue to react with MAO inhibitors.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

Symptoms of unusually high blood pressure (hypertensive crisis)

• Chest pain (severe)


• enlarged pupils


• fast or slow heartbeat


• headache (severe)


• increased sensitivity of eyes to light


• increased sweating (possibly with fever or cold, clammy skin)


• nausea and vomiting


• stiff or sore neck

Check with your doctor as soon as possible if any of the following side effects occur:

More common

• Dizziness or lightheadedness (severe), especially when getting up from a lying or sitting position

Less common

• Diarrhea


• fast or pounding heartbeat


• swelling of feet or lower legs


• unusual excitement or nervousness

Rare

• Dark urine


• fever


• skin rash


• slurred speech


• sore throat


• staggering walk


• yellow eyes or skin

Symptoms of overdose

• Anxiety (severe)


• confusion


• convulsions (seizures)


• cool, clammy skin


• dizziness (severe)


• drowsiness (severe)


• fast and irregular pulse


• fever


• hallucinations (seeing, hearing, or feeling things that are not there)


• headache (severe)


• high or low blood pressure


• muscle stiffness


• sweating


• trouble in sleeping (severe)


• troubled breathing


• unusual irritability

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Blurred vision


• decreased amount of urine


• decreased sexual ability


• dizziness or lightheadedness (mild), especially when getting up from a lying or sitting position


• drowsiness


• headache (mild)


• increased appetite (especially for sweets) or weight gain


• increased sweating


• muscle twitching during sleep


• nausea


• restlessness


• shakiness or trembling


• tiredness and weakness


• trouble in sleeping

Less common or rare

• Chills


• constipation


• decreased appetite


• dryness of mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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